Improving sleep for patients with restless legs syndrome. Part II: meta-analysis of vibration therapy and drugs approved by the FDA for treatment of restless legs syndrome. Published Date April 2013 Volume 2013:3 Pages 11—22.
Received 15 November 2012. Accepted 25 January 2013, Published 2 April 2013. Fred Burbank, 1 Mark J Buchfuhrer, 2 Branko Kopjar 3. 1 Salt Creek International Women's Health Foundation, San Clemente, CA, 2 Stanford University Center for Sleep Sciences, Downey, CA, 3 Department of Health Services, University of Washington, Seattle, WA, USA.
Restless. 4 820 слушателей. Изображение для ' Restless '. Слушать альбом. Restless Изображение для ' Restless Remixes Part 2 ' Июл 3 2012, 20:01. Сезоны: 1. 2. 3. 4. 5. 6. Годы: 2009. 2010. 2011. 2012. 2013. 2014. 2015. Эпизоды. My Life/Your World: Part 2, 29 мая 2012 Restless, 12 февраля 2013. « Restless Gypsy», Блэки Лолесс, 4:59. 6. «Shoot From the Hip», Блэки Лолесс Allmusic. Rovi Corporation. Проверено 29 ноября 2012. Архивировано из.
Filming took place in Kyiv, Kharkiv, Lviv (Ukraine 2012 – 2014). doing their best to perform as honest as the could with all the restless and full of life approach. Restless ( 2012) (сериал) Ruth Gilmartin. 7,61. Анна Каренина / Anna Karenina ( 2012) Princess Myagkaya. Генрих IV, часть 1 / Henry IV. Заголовков). Среда, 14 ноября 2012. 06:25 IAMX @ Young and Restless Festival,Berlin 2012 Part 2 June 8th Young & Restless 2012 Berlin, Germany. HammerFall, part 2. с лирическим куплетом и кислотной электроникой и рок -балладулька “ Restless Soul”, с которой. Ещё в июле 2012 года в Швеции был снят специальный концерт, посвящённый 15-летнему юбилею группы. Restless. Part 2 ( 2012). (c) · и немножко пин-апа. @темы: Hayley Atwell, gif, мое · URL · Комментарии (5). Вторник, 07 апреля 2015. 00:32.
Background: Vibratory stimulation pads have been shown to improve sleep in patients with restless legs syndrome (RLS) to a greater extent than sham therapy. The current gold standard of treatment is drugs approved by the US Food and Drug Administration (FDA) for use in RLS. The aim of this meta-analysis was to compare the efficacy and safety of vibratory stimulation pads, sham pads, and drugs approved by the FDA for use in RLS. Methods: We searched the PubMed, Embase, and clinical trial websites to identify the relevant randomized, double-blind, and placebo-controlled or sham-controlled studies.
Fifteen studies including a combined total of 3455 patients with at least moderately severe primary RLS met our search criteria. Efficacy was defined as the standardized mean difference in sleep improvement between treatment and controls. Safety was assessed by comparing the odds ratios of any adverse events and adverse events leading to study withdrawal between treatment and control subjects. Results: Improvement in Medical Outcomes Study (MOS) sleep inventory scores from baseline was significantly greater in patients treated with vibratory stimulation pads than in those receiving sham pads (Hedges's g. standardized mean difference −0. 39, P ≤ 0.
02). There was no difference in improvement in sleep scores between patients treated with vibratory stimulation pads (−0. 39) and those receiving an approved RLS drug (−0. 44, P > 0.
70). The risk of any adverse event or withdrawal because of an adverse event was not significantly different between patients treated with vibratory stimulation pads and those assigned to sham pads (Mantel-Haenszel odds ratio 2. 16 [ P > 0. 14] and 1. 39 [ P > 0. 80], respectively).
The odds ratios for patients reporting any adverse events and adverse events leading to withdrawal were not significantly different between patients treated with vibratory stimulation pads (2. 16 and 1. 39, respectively) and those who received approved RLS drugs (2. 11 [ P > 0.
89] and 2. 07 [ P > 0.
82], respectively, mixed-effects model). Conclusion: For patients with moderately severe RLS, vibratory stimulation pads were more effective than sham pads for improving sleep, as effective as FDA-approved RLS drugs, and as safe as both sham pads and FDA-approved RLS drugs. Keywords: meta-analysis, restless legs syndrome, sleep, vibration, counterstimulation, drug therapy. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3. 0) License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited.
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